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COMPREHENSIVE ANALYSIS OF CHEMOKINES AND CYTOKINES SECRETED IN THE PERITONEAL CAVITY DURING LAPAROTOMY
2012
Journal of immunoassay & immunochemistry
& We recently found that chemokine-driven peritoneal cell aggregation is the primary mechanism of postoperative adhesion in a mouse model. To investigate this in humans, paired samples of peritoneal lavage fluid were obtained from seven patients immediately after incision (preoperative) and before closure (postoperative), and were assayed for the presence of 27 cytokines and chemokines using multiplex beads assay. As a result, IL-6 and CCL5 showed the most striking increase during operation.
doi:10.1080/15321819.2011.638409
pmid:22738652
pmcid:PMC3431549
fatcat:lplma4rruvaovbnmkmnjiyfibq