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Human Trabecular Meshwork Cell Volume Decrease by NO-Independent Soluble Guanylate Cyclase Activators YC-1 and BAY-58-2667 Involves the BKCaIon Channel
Investigative Ophthalmology and Visual Science
PURPOSE. There is a correlation between cell volume changes and changes in the rate of aqueous humor outflow; agents that decrease trabecular meshwork (TM) cell volume increase the rate of aqueous humor outflow. This study investigated the effects of the nitric oxide (NO)-independent activators of soluble guanylate cyclase (sGC), YC-1, and BAY-58-2667 on TM cell volume and the signal transduction pathways and ion channel involved. METHODS. Cell volume was measured with the use of calcein AMdoi:10.1167/iovs.08-3127 pmid:19234350 fatcat:sbp74gzkyfaklksf6fhmr65agi