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Cystamine Inhibits Caspase Activity
Journal of Biological Chemistry
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormally expended polyglutamine domain. There is no effective treatment for HD; however, inhibition of caspase activity or prevention of mitochondria dysfunction delays disease progression in HD mouse models. Similarly administration of cystamine, which can inhibit transglutaminase, prolonged survival of HD mice, suggesting that inhibition of transglutaminase might provide a new treatment strategy.doi:10.1074/jbc.m205812200 pmid:12458211 fatcat:sau6abnu5reftaar5nu4xhexfe