Role of the Immunological System in the Initiation and Progression of Atherosclerosis

Delgado Livan, Roche
Atherosclerosis is a chronic inflammatory disease that is considered as major cause of death in the western world. Many studies and observations suggest that it could be caused by immunological reactions against autoantigens at the endothelial level, the most relevant of which are oxidized low-density lipoproteins and heat shock proteins 60/65. Experimental and clinical observations confirm the pathological role of these antigens during atherogenesis. Both innate and adaptive immunity and
more » ... immunity and impaired regulatory mechanisms of the autoimmune reaction are involved in the atherogenic development. The aim of the present work was to examine the immunological mechanisms that contribute with the initiation and progression of atherosclerosis and also offer an overview of the recent advances in this field.