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The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies. Despite the promising capability of systems biology and bioinformatics to handle large data sets, data interpretation, especially the translation of -omics data into clinical implications, has been challenging. Discussion: In this perspective, some important conceptual and technological limitations of current systems biology are discussed in the context of the ultimate importance ofdoi:10.2174/1389202918666170717145716 pmid:29606910 pmcid:PMC5850511 fatcat:lwojec3zara6be4zfqouphusc4