Biomedical research networks need to integrate research data among their members and with external partners. To support such data sharing activities, adequate information technology infrastructure is necessary. To facilitate the establishments of such an infrastructure, we developed a reference model for requirements. The reference model consists of five reference goals and 15 reference requirements. Using the Unified Modeling Language, the goals and requirements are set into relation to each

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... her. In addition, all goals and requirements are described textually in tables. This reference model can be used by research networks as a basis for the resource efficient acquisition of their project specific requirements. Further, a concrete instance of the reference model is described for a research network on liver cancer. The reference model is transferred into a requirements model of the specific network. Based on this concrete requirements model, a serviceoriented information technology architecture is derived and also described in this paper. Abstract 17 Biomedical research networks need to integrate research data among their members and with external 18 partners. To support such data sharing activities, adequate information technology infrastructure is 19 necessary. To facilitate the establishments of such an infrastructure, we developed a reference model 20 for requirements. The reference model consists of five reference goals and 15 reference requirements. 21 Using the Unified Modeling Language, the goals and requirements are set into relation to each other. In 22 addition, all goals and requirements are described textually in tables. This reference model can be used 23 by research networks as a basis for the resource efficient acquisition of their project specific 24 requirements. Further, a concrete instance of the reference model is described for a research network 25 on liver cancer. The reference model is transferred into a requirements model of the specific network. 26 Based on this concrete requirements model, a service-oriented information technology architecture is 27 derived and also described in this paper. 28