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The role of glucocorticoids in the regulation of apoptosis remains incongruous. Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21 Waf1/Cip1 . In primary cortical neurons, corticosterone leads to a dose-and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21 Waf1/Cip1 at Thr 145. Exposure of neurons to the neurotoxin ethylcholine aziridinium (AF64A) results indoi:10.1523/jneurosci.5110-06.2007 pmid:17460069 fatcat:nfce4w7xdnfp5bf7ab5drzoeaq