Digitalis in the Sick Sinus Syndrome

TOBY R. ENGEL, STEPHEN F. SCHAAL
1973 Circulation  
The effect of digitalis in patients with sinoatrial node dysfunction was studied. Atrial pacing studies were performed while His bundle -electrograms were recorded in fourteen patients with sinus bradyeardia, syncope, or related symptoms. Measurements were repeated after 0.01 mg/kg ouabain, followed in some by 1 mg atropine. Ouabain produced a significant shortening of sinoatrial recovery time, but no significant change in heart rate. Atropine normalized sinoatrial recovery times in most
more » ... imes in most patients. This study demonstrates that digitalis causes an increase in automaticity in the sick sinus syndrome as reflected by a shortened sinoatrial recovery time.
doi:10.1161/01.cir.48.6.1201 pmid:4762477 fatcat:mbco5wic4bfxjf6b7ypntbz7cm