Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer [report]

James A. Talcott
2007 unpublished
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more » ... torate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. implants, theoretically may increase the target radiation dose and thus improve control of cancer. has been rapidly adopted in the U.S. despite limited long-term published outcomes, in part because of its convenience apparently attractive toxicity profile. However, our recent survey of brachytherapy patients after longer follow-up surprisingly frequent urinary incontinence and erectile dysfunction. Retrospective evidence suggests that reducing theradiation dose to the urethra may prevent later urinary incontinence. A recent refinement of conventionalbrachytherapy technique targets only the peripheral zone of the prostate, sharply reducing the dose to the urethra, andattempts to reduce radiation "cold spots" by using intraoperative feedback from real-time magnetic resonance imaging(MRI). Using our validated cancer-specific scales, our pilot data suggested that the altered brachytherapy technique hadthe intended benefit but also unexpected outcomes. We have extended our cohort study of 276 brachytherapy patientsand now compare 3-and 24-month outcomes of this technique to standard ultrasounded-guided brachytherapy. SUBJECT TERMS Quality of Life, Outcomes, bowel symptoms, sexual function, questionnaires, magneticresonance imagin 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON USAMRMC a. REPORT U b. ABSTRACT U c. THIS PAGE U UU 18 19b. TELEPHONE NUMBER (include area code) Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18
doi:10.21236/ada466561 fatcat:txtofzjyb5fm5g37e43m5m33vi