INDICATORS MEDIUM-WEIGHT MOLECULES AS A CRITERION FOR OBJECTIVE EVALUATION OF THE QUALITY OF LIFE IN PATIENTS WITH ACUTE MYELOID LEUKEMIA

Kubarova, Basova
unpublished
Anoshina M.J., Goryainova The aim of the work was to determine the parameters of medium-weight molecules (MWM) in patients with acute myeloid leukemia (AML) in the onset of the disease and after induction chemotherapy. The object of the study was the blood serum of 36 patients with AML in first acute period between the ages of 25 to 74 years, which were observed in the department of diseases of the blood SI "IHT NAMSU." Content in the serum was determined by measuring the MWM at a wavelength of
more » ... 254 nm acid-soluble fraction MWM 254 , which indicates the level of intense proteolytic intermediates having a molecular weight of 1000D to 2000D and a wavelength of 280 nm acid-soluble fraction MSM 280 resulting from the accumulation of biologically active substances with a molecular weight of 2000D to 5000D. However, the light absorbance at 254 nm and 280 nm is not fully display elevated levels of biologically active oligopeptides, which cause discoordination metabolic processes in the body. Therefore, the range was increased and the measurement was performed at a wavelength of 238 nm, 254 nm, 260 nm and 280 nm with the calculation of peptide / nucleotide coefficients and aromaticity (K 238/260 and K 238/280 , respectively). Also determined the distribution ratio of K 280/254. It is proved that in patients with AML at the onset of the disease is worsening endogenous intoxication by raising three of the four acid-soluble fractions of MWM. Correlation analysis of the data showed that the onset of the disease indicators MWM have a close relationship with some of the main prognostic factors and biochemical markers of liver function and kidney. Research and data correlation analysis suggests the appropriateness and legality of the use of indicators MWM as an objective criterion for assessing the quality of life of patients with AML. Резюме Аношина М.Ю., Горяінова Н.В., Кубарова В.О., Басова О.В. ДУ «Інститут гематології та тра-нсфузіології НАМН України», вул. М.Берлинського, 12, Київ, 01001, Укриїна ПОКАЗНИКИ МОЛЕКУЛ СЕРЕДНЬОЇ МАСИ ЯК КРИТЕРІЙ ОБ'ЄКТИВНОЇ ОЦІНКИ ЯКОСТІ ЖИТТЯ ХВОРИХ НА ГО-СТРУ МІЄЛОЇДНУ ЛЕЙКЕМІЮ Метою роботи було визначення показників молекул середньої маси (МСМ) у хворих на гостру мієлоїдну лейкемію (ГМЛ) у де-бюті захворювання та після проведення індукційної хіміотерапії. Об'єктом досліджень була сироватка крові 36 хворих на ГМЛ у першому гострому періоді у віці від 25 до 74 років, які надійшли у
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