The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. Since the publication of the last revision of this FGE the EFSA has been requested to evaluate one additional

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... de .088] which has been included in the present version of FGE.74. Therefore, the present consideration concerns a group of 19 simple aliphatic sulphides and thiols evaluated by the JECFA at the 53 rd meeting in 1999 and the 61 st meeting in 2003. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel agrees with the application of the Procedure as performed by the JECFA for eight substances [FLfor the preparatory work on this scientific Opinion. Flavouring Group Evaluation 74 Rev2 2 EFSA Journal 2011; 9(12):2458 one substance ], which has been cleared by the JECFA at step B5 (the MSDI < 1.5 μg person per day), that adequate NOAELs exist and accordingly concluded at step B4, "No safety concern at the estimated level of intake". Furthermore, for the eight substances 12.013, 12.020, 12.023, 12.045, 12.074, 12.155 and 12.280], contrary to the JECFA, the Panel concluded that no adequate NOAEL exists and that additional toxicity data are required. For two of these substances , European production volumes are not available. Finally, for the two tertiary thiols ], contrary to the JECFA, the Panel concluded that these two substances should not be evaluated using the Procedure due to concern for genotoxicity. So, the Panel concluded that nine substances 12.179, 12.198, 12.212, 12.238, 12.239, 12.255, 12.257 and 12.291 do not give rise to safety concern at their levels of dietary intake, estimated on the basis of the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered for the substances evaluated through the Procedure and for three substances 12.239 and 12.291] the stereoisomeric composition has to be specified. SUMMARY The European Food Safety Authority (EFSA) asked the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC and its consecutive amendments. For the remaining six JECFA evaluated simple aliphatic sulphides and thiols 12.179, 12.198, 12.212, 12.255 and 12.257] the Panel agrees with the JECFA conclusion "No safety concern at estimated levels of intake as flavouring substances" based on the MSDI approach.