The Factors Affecting Recurrence and Prognosis in Patients with Low-grade Stage Ta Bladder Cancer

Mustafa Latif Özbek, Mehmet Özen, Süleyman Öner, Fatih Kocamanoğlu, Murat Gülşen, Mehmet Necmettin Mercimek, Yakup Bostancı, Şaban Sarıkaya
2021 Üroonkoloji Bülteni  
Objective:This study aims to review the parameters affecting tumour recurrence, tumour progression and cancer survival of patients with low-grade non-muscle invasive bladder cancer.Materials and Methods:We retrospectively reviewed 262 patients with primary, low-grade Ta bladder cancer. Recurrence was defined as the occurrence of a new tumour in the prostatic urethra or bladder. Tumour progression was defined as confirmed high-grade Ta, all T1 or carcinoma in situ, upper tract recurrence or
more » ... ession to T2. The associations between factors that affect recurrence and progression were analysed.Results:Tumour recurrence and progression occurred in 119 (45.4%) and 25 (9.5%) patients during follow-up (median follow-up: 50.9±36.3 months), respectively. Univariate and multivariate analyses demonstrate that smoking, multiple tumours and large tumours (3 cm<) were significant. A Cox regression analysis revealed that progression was identified as a significant risk factor on survival. There was no effect of smoking on recurrence-free survival. A Kaplan-Meier analysis showed that one-, five- and ten-year progression-free survival rates were 99.6%, 88.2% and 70%, respectively.Conclusion:Multiple tumours, large tumours (>3 cm) and smoking were risk factors for recurrence and progression. Prevention of smoking and routine cystoscopic examination are essential in bladder cancer.
doi:10.4274/uob.galenos.2020.1558 doaj:6fb456cb7d12467bbea9d17526d5f244 fatcat:voojppnjora75ieevfejozu26m