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Hexachlorophene as a topically applied chemical for prophylaxis against Schistosoma mansoni infections in mice
Revista do Instituto de Medicina Tropical de São Paulo
Treatment of mouse tail skins with hexachlorophene (1.25% w/v) in absolute methanol or 70% isopropanol suppressed Schistosoma mansoni infections by more than 95% even when the application was performed up to three days prior to exposure to cercarial suspensions by tail immersion. Treatment with concentrations of 0.313% or higher one day prior to exposure provided at least 98% protection when the treated surface was not subjected to water washes of greater duration than 1/2 hour. Tail immersiondoi:10.1590/s0036-46651985000400006 pmid:3938564 fatcat:5qv7iwhtvbax7pq6da44vpwv5y