Luteolin Inhibits Breast Cancer Development and Progression In Vitro and In Vivo by Suppressing Notch Signaling and Regulating MiRNAs

Da-Wei Sun, He-Da Zhang, Ling Mao, Chang-Fei Mao, Wei Chen, Meng Cui, Rong Ma, Hai-Xia Cao, Chang-Weng Jing, Zhuo Wang, Jian-Zhong Wu, Jin-Hai Tang
2015 Cellular Physiology and Biochemistry  
This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. Abstract Background/Aims: This study aims to investigate the effect of Luteolin on breast cancer in vitro and in vivo and the interaction between miRNAs and Notch signaling after Luteolin intervention, and illustrates the
more » ... and illustrates the possible underlying mechanism and regulation loop. Methods: Cell growth/survival assays and cell cycle analyses were performed to evaluate cell survival in vitro. Scratch tests, cell invasion assays and tube formation assays were carried out to
doi:10.1159/000438535 pmid:26545287 fatcat:wzehmqm2fzdctbno4ezc7xl4na