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HDAC3 acts as a negative regulator of angiogenesis
2014
BMB Reports
Histone deacetylase-3 (HDAC3) is involved in cellular proliferation, apoptosis and transcriptional repression. However, the role of HDAC3 in angiogenesis remains unknown. HDAC3 negatively regulated the expression of angiogenic factors, such as VEGF and plasminogen activator inhibitor-1 (PAI-1). HDAC3 showed binding to promoter sequences of PAI-1. HDAC3 activity was necessary for the expression regulation of PAI-1 by HDAC3. VEGF decreased the expression of HDAC3, and the down-regulation of HDAC3
doi:10.5483/bmbrep.2014.47.4.128
pmid:24286308
pmcid:PMC4163891
fatcat:2fk35e6l2rdu3oilulxlmiaowm