Mechanism of Cyanide Toxicity and Efficacy of its Antidotes

S. K. Raza, D. K. Jaiswal
1994 Defence Science Journal  
This paper attempts to review the various antidotes available for countering cyanide threat in the light of the toxicity associatcd with it. It also critically evaluates the drawbacks and advantages of these antidotes for their thcrapcutic and/or prophylactic utility. The physico-chemical properties of hydrogen cyanide which make it a chemical warfare agent have also been highlighted. In an attempt to make the complex chemical and biological processes understandable, the chemical structures of
more » ... ical structures of the antidotes have been included ~nd simple mechanistic pathways have been used to show the role of antidotes in activating the inhibited enzymes.
doi:10.14429/dsj.44.4188 fatcat:6rtbyxeyzffnlgict7cdcpa5pm