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The Epstein–Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins
2013
Nucleic Acids Research
Viral proteins reprogram their host cells by hijacking regulatory components of protein networks. Here we describe a novel property of the Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA1) that may underlie the capacity of the virus to promote a global remodeling of chromatin architecture and cellular transcription. We found that the expression of EBNA1 in transfected human and mouse cells is associated with decreased prevalence of heterochromatin foci, enhanced accessibility of cellular DNA
doi:10.1093/nar/gkt032
pmid:23358825
pmcid:PMC3597695
fatcat:ecipdhiiindorkasmuqqwuo6xe