Functional Analysis of trk Proto-oncogene Product in Medulloblastoma Cells

Takashi KOKUNAI, Hideki SAWA, Norihiko TAMAKI
1996 Neurologia medico-chirurgica  
MED-L cells with the 75 kd low-affinity nerve growth factor receptor (p75NGFR) and MED-H cells with the proto-oncogene tropomyosin receptor kinase product (p140trk) were isolated selectively from a par ent MED-3 cell line derived from cerebellar medulloblastoma by panning, and the interaction of nerve growth factor (NGF) with these cell lines was analyzed. NGF treatment induced neuronal differentia tion, growth inhibition, and tyrosine phosphorylation of p140trk in MED-H cells, but not in MED-L
more » ... cells. Medulloblastoma cells express the functional NGFR, p140trk, which regulates their differentia tion and growth.
doi:10.2176/nmc.36.796 pmid:9420431 fatcat:lyot4nn4zre6zfj34fc3onr3bi