The present research explores the traditional usage of Annona cherimola and validates its usage experimentally against diabetic complication and oxidative stress. Results of proximal constituents illustrated higher ash content (89.6%) representing edible nature and contains required amount of micro and macronutrients. In vitro α amylase inhibition assay with 26-57% inhibition justifies the usage of Annona cherimola to combat diabetes, further treatment with Annona cherimola extract to alloxan

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... duced diabetic rats showed significant activity against diabetes by regulating the release of Insulin (46-159%), C-peptide (61-72%), maintaining the levels of GHb (1-28/%) and atherogenic index. Similarly, the altered renal (urea, uric acid and creatinine) and liver markers (SGOT, SGPT and ALP) was significantly reverted back to near normal levels after treatment. Meanwhile, enzymatic antioxidant (SOD, CAT) levels demonstrated the improvement in radical scavenging potential in liver and kidney tissues of diabetic rats after treatment. An attempt is made to understand the relationship between physiological responses associated with regulation of body temperature using animal surface temperature images captured with infrared camera. Whole body asymmetrical temperature distribution analysis results revealed significant temperature change in experimental animals with 1 to 5% carried out in abdominal area and observed reduction in temperature during treatment. Volume 1 -Issue -5 hemoprotein that catalyses the decline of hydrogen peroxide and defends the tissues from the effect of hydroxyl radicals [34] . The predominant raise in liver SOD and CAT after treatment with Annona cherimola (250 and 500mg/kg b.w) indicates its beneficial action. The results of antioxidant in diabetic treated are as similar to the action with standard drug glibenclamide (10mg/kg b.w) ( Table 6) . Similar results were observed in previous reports of antidiabetic effect of Dilleniaindica L. leaves in diabetic rats [35] .