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Understanding of cell-type specific transcription factors has promoted progress in methods for cellular reprogramming, such as directly reprogramming somatic cells to induced neurons (iN). Methods for direct reprogramming require neuronal-fate determining gene activation via neuron-specific microRNAs, chemical modulation of key neuronal signaling pathways or overexpression via viral vectors, with some reprogramming strategies requiring a combination of these methods to induce the neuronal-celldoi:10.3389/fgeed.2020.00007 pmid:34713216 pmcid:PMC8525349 fatcat:yx7wz4xqmnfpblsymc4dyjknvq