COAGULATION PROFILE AS IMPORTANT MARKERS IN PREECLAMPSIA AND ECLAMPSIA

Talat Fatma, ShamimKhurrum Azmi, AjitKumar Chaudhary
2017 International Journal of Advanced Research  
Materials and methods: 140 pregnant women between 17yrs to 30 yrs age were included in the study. Among these women there were 41 %( n=68) cases of preeclampsia, 23% (n=32) cases of eclampsia and remaining 29 %( n= 40) women with normal pregnancy in third trimester were taken as control. 64.7 % (n=44) of preeclamptic women were 20 yrs to 25 yrs of age. 50% (n=16) women with eclampsia were 20-25 yrs of age. Nulliparous women were higher in pre-eclamptic group (52.9%) whereas only 25% of
more » ... nly 25% of eclamptic women were nulliparous. In this study group all patients except 4 were in third trimester of pregnancy, 47.1% of pre eclamptic group and 37.5% of eclamptic group were in early third trimester of pregnancy. Four eclamptic women (12.5%) were in 25 weeks gestation. The coagulation parameters tested were bleeding time, clotting time, prothrombin time, thrombin time, activated partial thromboplastin time, plasma fibrinogen, and platelet count. The values of coagulation parameters were statistically analysed in preeclamptic, eclamptic and control group. Results: Bleeding time (B.T):  Difference in mean value of preeclamptic (2.45 ± 0.48 S.D.) with that of normal (2.3 ±0.19 S.D.) difference was insignificant (p<0.1)  Difference in mean value of B.T. of eclamptic (2.94 ± 0.47 S.D.)with that of normal (2.3 ±0.19 S.D.) was significant (p<0.001) Clotting time (C.T.):  Difference in mean value of C.T. of preeclamptic (4.23± 0.37 S.D.) and normal (4.2 ±O.37 S.D) was statistically insignificant (p<0.1).
doi:10.21474/ijar01/4370 fatcat:vlg2gf3akvgr5p5vylafz26h5q