Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface

C. Piccirillo, S. Perni, J. Gil-Thomas, P. Prokopovich, M. Wilson, J. Pratten, I. P. Parkin
2009 Journal of Materials Chemistry  
Methylene Blue or Toluidine Blue O were covalently bound to an activated silicone polymer by means of an amide condensation reaction. UV-visible absorption spectra confirmed that the dye was surface bound. The new polymers with covalently attached dye display significant bactericidal activity against Escherichia coli and Staphylococcus epidermidis with a 99.999% reduction in viable bacteria after four minutes exposure to a low power laser.
doi:10.1039/b905495b fatcat:yjdy6y5gd5fibkk2e3ddwn3kem