Periorbital necrobiotic xanthogranuloma without paraproteinemia

Taeko Nakamura-Wakatsuki, Toshiyuki Yamamoto
2013 Nasza Dermatologia Online  
Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disease which most frequently involves periorbital areas. NXG is associated with paraproteinemia with a ratio over 80%. However, a few cases of NXG without paraproteinemia (isolated NXG) have also been reported. Main observation: A 58-year-old Japanese woman complained about asymptomatic dermal nodules on the bilateral lower eyelids. The histopathological examination revealed granulomatous inflammation. Paraproteinemia was not detected
more » ... er in the serum or in the urine. The size of the nodules has been constant, and she has been under careful follow-up without any systemic therapies. Conclusions: NXG is frequently associated with paraproteinemia, which may develop later. Patients with NXG need careful follow-up including repeated blood tests.
doi:10.7241/ourd.20133.84 fatcat:wfxpqspitnh7zbxsfkkh3opn3m