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Seeking "Etwas Neues"—From Bioorganic Chemistry to Alzheimer's Disease—
2008
Yakugaku zasshi
Introduction to bioorganic chemistry by Prof. Kanaoka at the entrance of my research works aŠects greatly throughout the life afterward. Chemical modiˆcation studies of enzyme proteins taught me quality of chemical reactions. For example, triethyloxonium ‰uoroborate (Et 3 O + BF -4 ), a Meerwein reagent, selectively reacted with a particular carboxyl group (Asp-177) in the substrate binding site of trypsin, even though the reaction was performed in aqueous solution. A series of ion channel
doi:10.1248/yakushi.128.1631
pmid:18981699
fatcat:kocsmbq4tfb5vdo24sngo7btqq