Gelatinase B and A Expression After Laser In Situ Keratomileusis and Photorefractive Keratectomy

Dimitri T. Azar
1998 Archives of Ophthalmology  
Objective: To compare the expression of gelatinases in the corneal epithelium and stroma after laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). Methods: Rabbit eyes were treated with LASIK (n=11), PRK (n=12), or corneal flap construction (n=12); 4 eyes served as unwounded controls. Zymography was performed on the central epithelium and the stroma 1, 3, and 7 days after surgery to determine the expression of gelatinases. Results: Epithelial expression of gelatinase B
more » ... the LASIK group (0%-25%) was lower than that in the PRK group at all time points (50%-100%) and was identical to the
doi:10.1001/archopht.116.9.1206 pmid:9747680 fatcat:p7c26bxdqzc4vl6adeso2mixci