tality were significantly higher in patients with reduced EF than those without (all p<0.01). In-hospit and 1-year outcomes in Study 1 n (%) Reduced EF (n=613) Non-reduced EF (n=8534) P value In hospital mortality 38 (6.2) 68 (0.8) <0.001 Heart failure post PCI 40 (6.5) 125 (1.5) <0.001 Acute kidney injury 107 (20.9) 880 (12.0) <0.001 Bleeding complications 36 (5.9) 241 (2.8) <0.001 1 year mortality 21 (8.5) 71 (2.0) <0.001 Conclusions: STEMI and silent ischemia were both frequent indications

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... r PCI in patients with LV dysfunction. LV dysfunction was at greater risk for in-hospital complication and 1-year prognosis after PCI. Background: The impact of contrast-induced persistent renal damage (CI-PRD) after contrast-induced acute kidney injury (CI-AKI) has not been studied extensively, and remains unknown. Purpose: The aim of the study is to assess the clinical outcome of CI-PRD in a large population of all-comers patients undergoing percutaneous coronary procedures. Methods: Serum creatinine (SCr) level of 881 patients was measured at baseline and at 12-24 hours, 48-72 hours, 20-40 days from contrast medium exposure and then retrospectively analyzed. Early and long-term clinical outcome were assessed with outpatient clinic visits or phone contact. Results: CI-AKI occurred in 106 (12.03%) out of 881 patients. Among those patients who developed CI-AKI, 35 (33.02%) manifested consecutively CI-PRD. During a mean observation time of 32±11 months, 107 patients (12.14%) presented the composite adverse outcome consisting of death, myocardial infarction, stroke or need for dialysis. Diabetes (HR 2.13; 95% CI 1.41-3.22; p<0.001), basal SCr (HR 1.36; 95% CI 1.21-1.52; p<0.001), CI-AKI (HR 1.94; 95% CI 1.25-3.01; p=0.003) and CI-PRD (HR 3.09; 95% CI 1.78-5.35; p<0.001) were associated with worse clinical outcome. At multivariate analysis CI-PRD remained an independent predictor of worse prognosis (HR 1.98; 95% CI 1.07-3.65; p=0.029) whereas CI-AKI failed to predict the composite adverse outcome (HR 1.58; CI 0.96-2.6; p=0.07) at follow up. Conclusion: The occurrence of CI-AKI, determined soon after contrast exposure, did not correlate with a worse long-term clinical outcome in this unselected population of patients. Conversely, patients showing a CI-PRD suffered a stronger clinical impact at long-term compared with transient CI-AKI.