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CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

Taylor W Foreman, Christine E Nelson, Keith D Kauffman, Nickiana E Lora, Caian L Vinhaes, Danielle E Dorosky, Shunsuke Sakai, Felipe Gomez, Joel D Fleegle, Melanie Parham, Shehan R Perera, Cecilia S Lindestam Arlehamn (+8 others)
2022

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https://web.archive.org/web/20220615003647/https://www.cell.com/cell-reports/pdf/S2211-1247(22)00671-4.pdf

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HIV/Mycobacterium tuberculosis (Mtb) co-infected individuals have an increased risk of tuberculosis prior to loss of peripheral CD4 T cells, raising the possibility that HIV co-infection leads to CD4 T cell depletion in lung tissue before it is evident in blood. Here, we use rhesus macaques to study the early effects of simian immunodeficiency virus (SIV) co-infection on pulmonary granulomas. Two weeks after SIV inoculation of Mtb-infected macaques, Mtb-specific CD4 T cells are dramatically
more » ... eted from granulomas, before CD4 T cell loss in blood, airways, and lymph nodes, or increases in bacterial loads or radiographic evidence of disease. Spatially, CD4 T cells are preferentially depleted from the granuloma core and cuff relative to B cell-rich regions. Moreover, live imaging of granuloma explants show that intralesional CD4 T cell motility is reduced after SIV co-infection. Thus, granuloma CD4 T cells may be decimated before many co-infected individuals experience the first symptoms of acute HIV infection.
doi:10.1016/j.celrep.2022.110896 pmid:35649361 fatcat:yelmj4mmzbcibpae7bujzz7m5q
Citation

Taylor W Foreman, Christine E Nelson, Keith D Kauffman, Nickiana E Lora, Caian L Vinhaes, Danielle E Dorosky, Shunsuke Sakai, Felipe Gomez, Joel D Fleegle, Melanie Parham, Shehan R Perera, Cecilia S Lindestam Arlehamn, Alessandro Sette, Tuberculosis Imaging Program, Jason M Brenchley, Artur T L Queiroz, Bruno B Andrade, Juraj Kabat, Laura E Via, Daniel L Barber. "CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection." (2022) 110896