COMPARISON OF RED CELL DISTRIBUTION WIDTH WITH SOFA SCORE AS A PROGNOSTIC MARKER OF SEPSIS IN ELDERLY PATIENTS
Journal of Evolution of Medical and Dental Sciences
BACKGROUND Severe sepsis and septic shock are increasing in incidence and contributing significantly to mortality. The prediction of outcome for elderly patients with sepsis may facilitate more aggressive interventions. The SOFA score is a scoring system used to quantify the severity of the patient's illness based on the degree of organ dysfunction. Various biomarkers are being evaluated for early diagnosis of sepsis. RDW is one of them, which have been shown to predict mortality and morbidity
... lity and morbidity of sepsis. Hence, this study is being done to compare RDW with SOFA score as prognostic marker of sepsis in elderly patients. AIM To compare red cell distribution width with SOFA score as a prognostic marker of sepsis in elderly patients. METHODS A total of 93 elderly patients in sepsis who were admitted to Intensive Care Unit of M. S. Ramaiah Hospitals between October 2013 and September 2015 were included in the study. ROC (Receiver Operating Curve) was used to determine the optimal cut-off point for RDW for predicting mortality. ROC of RDW was compared with ROC of SOFA score. RESULTS Mean age of the patients was 70.72±8.02 and most of the patients were in the age group of 61-70yrs. (53.8%). 52(55.9%) patients were males and 41(44.1%) patients were females. Bronchopneumonia (34.4%) and urosepsis (30.1%) were the most common causes of sepsis; 61.3% of the patients had SOFA score in the range of 5-10. Mean SOFA score was 7.87097±3.22769. Mean RDW was 14.247±2.1151. CONCLUSION RDW had a sensitivity of 81.6%, specificity of 77.3%, positive predictive value of 80%, and negative predictive value of 79.1% with a cut-off value of 13.75% in predicting mortality in elderly patients in sepsis.