Mixed-up about how to diagnose and treat mixed features in major depressive episodes

Stephen M. Stahl
2017 CNS Spectrums  
The classical point of view—that major depressive episodes (MDEs), no matter what additional symptoms are present, should be treated first line with antidepressants—is now giving way to new a notion. The idea is that MDEs mixed with a few symptoms of mania/hypomania should be viewed very differently in terms of their natural history, clinical outcome, and treatment, and perhaps certain antipsychotics should be given as first-line treatment rather than antidepressant monotherapy.
doi:10.1017/s1092852917000207 pmid:28271818 fatcat:zo54ko6oozhdfigogg5sic3bku