Adjuvant chemotherapy has been established as the standard of care for patients with node-positive resected colon cancer. 5-fluorouracil modulated with leucovorin given for six months is currently the most widely accepted "standard" regimen. The role of adjuvant chemotherapy in stage II remain investigational and some prognostic indicators that correlate with higher risk for subsequent recurrence may be used for these patients when consider adjuvant chemotherapy. Other investigational

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... include regional, portal vein infusion and intraperitoneal therapy, immunotherapy, and new drugs, with proven activity in metastatic disease. Patients older than 70 years are also candidate for adjuvant therapy of colorectal cancer. Adjuvant chemotherapy of rectal cancer is often associated with radiotherapy and enhances local control seen with radiotherapy and improves survival of these patients.