Frequent knee pain affects approximately 25% of adults, limits function and mobility, and impairs quality of life among adults around the world. Objective: To examine the effects of oral glucosamine supplementation on the functional ability and degree of pain felt by individuals who had regular knee pain.: Methods:This prospective, comparative cohort was carried out at Muhammad Medical College Hospital, Mirpurkhas from January 2016 to June 2018 on a sample of 84 patients presenting to the

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... edic outpatient department with complaint of regular knee pain (chosen via non-probability, consecutive sampling) aged 40 years and above. After taking written informed consent, patients were divided into two groups of 42 subjects each and administered either glucosamine or placebo (lactose). Data was collected using a self-structured questionnaire for sociodemographic details, the Knee Pain Questionanire (KPQ). Observations and expert evaluations were also noted. The data obtained was analyzed using MS. Excel 2013 and SPSS v. 21.0. Result: Among the subjects enrolled into the study, 52 were females while 32 were males. The mean B.M.I for females stood at 28.7 and 25.3 for males. The subjects reported with a mean (pre-intervention) KPQ score of 51 and a mean KPQ (post-intervention) of 21 for glucosamine group and 29 for placebo group. Conclusion:After carefully considering the results, it can be concluded that both groups experienced significant improvement in knee function and pain. Thus whether the difference was brought about by intervention or just time may be explored in future research. Keywords: Knee Pain, Osteoarthritis, Glucosamine, Pain Relief and Knee Function.