Cardiovascular progenitor cells and tissue plasticity are reduced in a myocardium affected by Becker muscular dystrophy

Martin Pesl, Sarka Jelinkova, Guido Caluori, Maria Holicka, Jan Krejci, Petr Nemec, Aneta Kohutova, Vita Zampachova, Petr Dvorak, Vladimir Rotrekl
2020 Orphanet Journal of Rare Diseases  
We describe the association of Becker muscular dystrophy (BMD) derived heart failure with the impairment of tissue homeostasis and remodeling capabilities of the affected heart tissue. We report that BMD heart failure is associated with a significantly decreased number of cardiovascular progenitor cells, reduced cardiac fibroblast migration, and ex vivo survival.
doi:10.1186/s13023-019-1257-4 pmid:32138751 fatcat:hvp3ipakpze5naw5z7udp6uz5u