The aim of this study was to find out the association between cigarette smoking and erythrocyte sedimentation rate (ESR) values and serum lipid profile in young smokers and compare it with age and weight matched non-smokers. The subjects consisted of 50 healthy cigarette smokers and 50 healthy, age and weight matched non-obese, non-smokers who served as controls. Subject in both groups were 25-35 years of age. They had no history of diabetes mellitus, hypertension, hepatic or renal disease,

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... ity, alcohol abuse and were not taking any medicines like P-blockers, diuretics or lipid lowering agents. Results showed significantly higher ESR values, serum total cholesterol (S.TC), low density lipoprotein cholesterol (LDL-C) and mean serum triglyceride (TG) levels, in smokers as compared to non-smokers. Mean serum high density lipoprotein cholesterol (HDL-C) was significantly lower in smokers as compared to non smokers. Conclusion: smoking produces rise in ESR values and adverse effects on Lipid profile, thus increasing the risk of atherosclerosis.