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A t a symposium titled "Adipose Tissue as a Secretory Organ" at the American Diabetes Association (ADA), San Francisco, June 2002, Jeffrey Flier (Boston, MA) discussed the effects of visceral obesity. While reviewing the differing components of the metabolic syndrome, which to large extent are driven by insulin resistance, he asked, "Where does the insulin resistance come from?" R e v i e w s / C o m m e n t a r i e s / P o s i t i o n S t a t e m e n t s P E R S P E C T Idoi:10.2337/diacare.25.12.2342 pmid:12453983 fatcat:574lnsjb3vhzvmwi7uvcxsvroe