Microalgae and lactic acid bacteria have become an innovative and promising resource of nutritional supplements as they are commercially cultivated to produce valuable compounds, including protein, pigments, lipids, essential amino acids, monounsaturated and polyunsaturated fatty acids, carotenoids, steroids and vitamins. The pharmacological actions, such as nutraceutical improvements, lowering LDL cholesterol levels, anti-inflammation, antioxidation, antitumor, immunological enhancement, and

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... patorenal protection from Spirulina spp and Lactic acid Bacillus have been reported recently. Based on the therapeutic potential of spriulina fermentation based lactic acid bacteria, different application studies such as, determining the effect of Spirulina fermentation with Lactic acid bacteria (FSL) on enhancing the Nutraceutical properties of Spirulina species, investigating the effect of Spirulina fermentation with Lactic acid bacteria (FSL) on lowering the LDL cholesterol and increasing HDL cholesterol, and evaluating the cytotoxic effect and influence of FSL on human cancer cell line was reviewed in the current article.