Characterization of N6-Cyclohexyladenosine-Induced Hypothermia in Syrian Hamsters

Mitsuteru Shintani, Yutaka Tamura, Mayuko Monden, Hirohito Shiomi
2005 Journal of Pharmacological Sciences  
The N 6 -cyclohexyladenosine (CHA)-induced hypothermia in Syrian hamsters was characterized as follows: intracerebroventricular injection of CHA-induced hypothermia and the potency was increased by lowering the ambient temperature. CHA microinjection into the anterior hypothalamus (AH) elicited the most marked body temperature (T b ) decrease compared with other regions such as the preoptic area, dorsomedial hypothalamus, posterior hypothalamus, and hippocampus. In contrast, microinjected CHA
more » ... to the medial septum, ventromedial hypothalamus, and lateral hypothalamus resulted in negligible changes in T b . These results suggest that CHA-induced hypothermia was probably due to suppression of thermogenesis via the site(s) of CHA action, viz., the AH and medial hypothalamus.
doi:10.1254/jphs.sc0040178 pmid:15764835 fatcat:g3ptkp5iwzekpabhrh3cay2jqq