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Transient downregulation of Bmp signalling induces extra limbs in vertebrates
Bone morphogenetic protein (Bmp) signalling has been implicated in setting up dorsoventral patterning of the vertebrate limb and in its outgrowth. Here, we present evidence that Bmp signalling or, more precisely, its inhibition also plays a role in limb and fin bud initiation. Temporary inhibition of Bmp signalling either by overexpression of noggin or using a synthetic Bmp inhibitor is sufficient to induce extra limbs in the Xenopus tadpole or exogenous fins in the Danio rerio embryo,doi:10.1242/dev.078774 pmid:22675213 fatcat:quba4rb4rzg37dhi5dawsrgmqq