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Genome-wide landscape of RNA-binding protein dysregulation reveals a major impact on psychiatric disorder risk
[article]
2020
bioRxiv
pre-print
Despite the strong genetic basis of psychiatric disorders, the molecular origins of these diseases are still largely unmapped. RNA-binding proteins (RBPs) are responsible for most post- transcriptional regulation, from splicing to translational to localization. RBPs thus act as key gatekeepers of cellular homeostasis, especially in the brain. Here, we leverage a deep learning approach to interrogate variant effects genome-wide, and discover that the dysregulation of RBP target sites is a
doi:10.1101/2020.05.19.102319
fatcat:2jmtkzmo3bbvjg54przkteessi