The effect of matured date palm tree (Phoenix dactylifera L.) fruit extract on miteinduced allergic symptoms in NC/Nga mice The effect of a hot water extract of matured date palm tree fruit on allergic responses was investigated in NC/Nga mice. The allergic score was significantly reduced in the mice fed a date palm tree fruit extract-added diet than the fruit extract-free diet. The levels of serum antigen-specific immunoglobulin E and spleen interleukin-4 + CD4 + cells were significantly

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... d in the mice fed the fruit extract-added diet. Bruton's tyrosine kinase and IL-2-inducible T cell kinase mRNA expressions in spleen cells were significantly lowered in the mice fed the fruit extract-added diet. Moreover, chlorogenic acid and pelargonin decreased these mRNA expressions in C3H/HeN mouse spleen cell cultures. These results suggest that the date palm tree fruit extract may reduce allergic symptoms in mice via a decrease in the number of type 2 helper T (Th2) cells, and a suppression of the expression of kinases involved in mast cell degranulation and Th2 cell differentiation.