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Statistical Frameworks for Oncology Dose-Finding Designs with Late-Onset Toxicities: A Review
[article]
2023
arXiv
pre-print
In oncology dose-finding trials, due to staggered enrollment, it might be desirable to make dose-assignment decisions in real-time in the presence of pending toxicity outcomes, for example, when the dose-limiting toxicity is late-onset. Patients' time-to-event information may be utilized to facilitate such decisions. We review statistical frameworks for time-to-event modeling in dose-finding trials and summarize existing designs into two classes: TITE designs and POD designs. TITE designs are
arXiv:2006.11676v3
fatcat:f47imh55zbcwtovlhl55mbxgdq