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Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross
2020
Cell Reports
Enhanced host protection against re-infection requires generation of memory T cells of sufficient quantity and functional quality. Unlike well-studied inbred mice, T cell responses of diverse size and quality are generated following infection of humans and outbred mice. Thus, additional models are needed that accurately reflect variation in immune outcomes in genetically diverse populations and to uncover underlying genetic causes. The Collaborative Cross (CC), a large recombinant inbred panel
doi:10.1016/j.celrep.2020.03.072
pmid:32294433
pmcid:PMC7212788
fatcat:hra372ww3nbndhgt7s3yvfsfwu