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Background. Losartan is a new specific angiotensin H receptor antagonist with no agonist properties that provides the opportunity to study the consequences of angiotensin II blockade. The objective of the present study was to evaluate the hemodynamic and neurohormonal response to losartan in patients with congestive heart failure. Methods and Results. After baseline hemodynamic measurements using balloon-tipped pulmonary artery and radial arterial catheters, patients were randomized to receivedoi:10.1161/01.cir.88.4.1602 pmid:8403307 fatcat:y5dwmclxs5f6lkxh4t6juwvkg4