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Effects of steroid hormones and peptide growth factors on protooncogene c-fos expression in human breast cancer cells
1988
Cancer Research
To investigate if the estrogen control of the tumorigenic phenotype of breast cancer cells was mediated through activation of the c-fos protooncogene, we examined the expression of this oncogene in MCF-7 cells. In cells synchronized by double thymidine blockade, the peptide growth factors transforming growth factor alpha and epidermal growth factor increased c-fos mRNA levels 6-fold above controls after 30 min of treatment. The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, increased
pmid:3257409
fatcat:dlazduxo7baj5cpkbs5vfhtlni