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Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass
1998
AJP - Renal Physiology
Urinary concentration characteristically decreases in response to a reduction in renal mass in chronic renal failure (CRF). In the present study, we examined whether there are changes in the expression of aquaporins in rats where CRF was induced by 5/6 nephrectomy. Plasma creatinine levels were significantly elevated consistent with significant CRF: 135.7 Ϯ 15.1 (n ϭ 17, CRF) vs. 33.9 Ϯ 1.1 µmol/l (n ϭ 11, sham), P Ͻ 0.05. Two weeks after 5/6 nephrectomy, the remnant kidneys were hypertrophied,
doi:10.1152/ajprenal.1998.275.5.f724
fatcat:5za3jwi4rvdkzhicjtpkpy5k7u