Density of calcium in the ascending thoracic aorta and risk of incident cardiovascular disease events

Isac C. Thomas, Robyn L. McClelland, Erin D. Michos, Matthew A. Allison, Nketi I. Forbang, W.T. Longstreth, Wendy S. Post, Nathan D. Wong, Matthew J. Budoff, Michael H. Criqui
2017 Atherosclerosis  
and aims-The volume and density of coronary artery calcium (CAC) both independently predict cardiovascular disease (CVD) beyond standard risk factors, with CAC density inversely associated with incident CVD after accounting for CAC volume. We tested the hypothesis that ascending thoracic aorta calcium (ATAC) volume and density predict incident CVD events independently of CAC. Methods-The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study of participants without clinical
more » ... VD at baseline. ATAC and CAC were measured from baseline cardiac computed tomography (CT). Cox regression models were used to estimate the associations of ATAC volume and density with incident coronary heart disease (CHD) events and CVD events, after adjustment for standard CVD risk factors and CAC volume and density.
doi:10.1016/j.atherosclerosis.2017.09.009 pmid:28917157 pmcid:PMC5646362 fatcat:vouu3pp5nfeltg5on6iwhv2mfa