Neurological Diseases from a Systems Medicine Point of View [chapter]

Marek Ostaszewski, Alexander Skupin, Rudi Balling
2016 Msphere  
The diffi culty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networks. These networks can become a useful research tool in investigating neurological disorders if they
more » ... re properly tailored to refl ect corresponding mechanisms. Here, we review approaches to construct networks specifi c for neurological disorders describing disease-related pathology on different scales: the molecular, cellular, and brain level. We also briefl y discuss cross-scale network analysis as a necessary integrator of these scales.
doi:10.1007/978-1-4939-3283-2_11 pmid:26677186 fatcat:jfrqbwg7uzchxcnweeq56vwdmu