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3-finger toxins (3FTxs) are a functionally diverse family of toxins, seemingly unique to the venoms of caenophidian snakes. Although the ancestral function of 3FTxs is antagonism of nicotinic acetylcholine receptors (nAChR), redundancy conferred by accumulation of duplicate genes has facilitated extensive neofunctionalization, such that derived members of the family interact with a range of targets. 3FTxs are members of the Ly6/uPAR family, but their precise non-toxin ancestor remains unknown.doi:10.1101/2022.12.15.520616 fatcat:ba5ixwflbvbuzfzr6xsbdzdudy