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Rewiring the Specificity of Two-Component Signal Transduction Systems
2008
Cell
Two-component signal transduction systems are the predominant means by which bacteria sense and respond to environmental stimuli. Bacteria often employ tens or hundreds of these paralogous signaling systems, comprised of histidine kinases (HKs) and their cognate response regulators (RRs). Faithful transmission of information through these signaling pathways and avoidance of detrimental crosstalk demand exquisite specificity of HK-RR interactions. To identify the determinants of two-component
doi:10.1016/j.cell.2008.04.040
pmid:18555780
pmcid:PMC2453690
fatcat:frhgiglfg5abln2auiza3m6elq