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The carcinogen, 7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, and a number of its noncarcinogenic derivatives form a reversible physical complex with DNA in vitro. The absorbance spectrum of the hydrocarbon in the complex shifts approximately 10 nm to the red. Fluorescence from the physically bound hydrocarbon is significantly quenched, and binding levels are decreased by the addition of 1) spermine, 2) MgCl2, and 3) NaCl, with their relative effectiveness in reducing complexpmid:6286655 fatcat:xcqzsxdjjffxbmqo2qx4zhpvmq