Recently, controlled and sustained drug delivery has become the standard in modern pharmaceutical design and an exhaustive research has been undertaken in achieving much better drug product efficacy, reliability and safety. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation from which the drug gets released in a controlled manner. They are biodegradable and generally have a good safety profile. Their composition can be

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... dapted to provide drug delivery over weeks or months after parentral extra vascular administration from a manufacturing point of view, the production of such devices is less complex and thus lowers the manufacturing cost. In this paper we studied the approaches, Method of preparation & recent advancement in situ gel. The primary requirement of a successful control release product focuses on increasing patient compliance, good stability and biocompatibility characteristics which make the in situ gel dosage forms very reliable. Use of biodegradable and water soluble polymers for the in situ gel formulation can make them more acceptable and excellent drug delivery systems.